MolNFT v1 · #158416 · protein
Cryo-EM structure of full-length chicken sting in the apo state
6NT6 · Stimulator of interferon genes protein: “Cryo-EM structure of full-length chicken sting in the apo state”. Electron microscopy, 11 pockets (best druggability 0.80). MolNFT v1 #158416 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6NT6
- Type
- protein
- Length
- 556 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Stimulator of interferon genes protein
- UniProt
- A0A1D5P7Q9
- Pockets
- 11 · best druggability 0.80
Structure
electron microscopy · 1 distinct chain · 60% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Stimulator of interferon genes protein | protein | 278 | 60% helix, 10% strand | A0A1D5P7Q9 |
Pockets
11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1073 | 0.80 | 0.81 | 68 | empty |
| 2 | 100 | 0.55 | 0.84 | 22 | empty |
| 3 | 240 | 0.55 | 0.77 | 24 | empty |
| 4 | 243 | 0.54 | 0.77 | 24 | empty |
| 5 | 101 | 0.51 | 0.82 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 4912 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- 6NT6 · Cryo-EM structure of full-length chicken STING in the apo state · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A1D5P7Q9
- Elsewhere: RCSB PDB 6NT6 · PDBe 6NT6 · UniProt A0A1D5P7Q9
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