MolNFT v1 · #158415 · protein
Cryo-EM structure of full-length human sting in the apo state
6NT5 · Stimulator of interferon protein: “Cryo-EM structure of full-length human sting in the apo state”. Electron microscopy, 14 pockets (best druggability 0.82). MolNFT v1 #158415 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6NT5
- Type
- protein
- Length
- 584 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Stimulator of interferon protein
- UniProt
- A0A2R3XZB7
- Pockets
- 14 · best druggability 0.82
Structure
electron microscopy · 1 distinct chain · 54% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Stimulator of interferon protein | protein | 292 | 54% helix, 10% strand | A0A2R3XZB7 |
Pockets
14 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 659 | 0.82 | 0.87 | 48 | empty |
| 2 | 224 | 0.71 | 0.86 | 26 | empty |
| 3 | 318 | 0.60 | 0.78 | 37 | empty |
| 4 | 368 | 0.59 | 0.76 | 29 | empty |
| 5 | 332 | 0.59 | 0.77 | 28 | empty |
Interfaces
1 interface between chains.
- A–B · 4576 Ų buried · 27 hydrogen bonds · protein-protein
Compared structures
- 6NT5 · Cryo-EM structure of full-length human STING in the apo state · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A2R3XZB7
- Elsewhere: RCSB PDB 6NT5 · PDBe 6NT5 · UniProt A0A2R3XZB7
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