MolNFT v1 · #15837 · protein
Chimeric mature Fab 7G12-apo
1NGY · Mature metal chelatase catalytic antibody, light chain: “Chimeric mature Fab 7G12-apo”. X-ray diffraction, 4 pockets (best druggability 0.62). MolNFT v1 #15837 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1NGY
- Type
- protein
- Length
- 429 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mature metal chelatase catalytic antibody, light chain; Mature metal chelatase catalytic…
- Pockets
- 4 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mature metal chelatase catalytic antibody, light chain | protein | 213 | 5% helix, 52% strand | — |
| B | Mature metal chelatase catalytic antibody, heavy chain | protein | 216 | 10% helix, 50% strand | — |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 565 | 0.62 | 0.75 | 71 | empty |
| 2 | 138 | 0.49 | 0.79 | 27 | empty |
| 3 | 80 | 0.36 | 0.76 | 14 | empty |
| 4 | 72 | 0.32 | 0.75 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1853 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 1NGY · Chimeric Mature Fab 7g12-Apo · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 1NGY · PDBe 1NGY
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