MolNFT v1 · #158292 · protein

Structure of the tm domain

6NPK · Solute carrier family 12 (SODIUM/POTASSIUM/CHLORIDE…: “Structure of the tm domain”. Electron microscopy, 15 pockets (best druggability 0.83). MolNFT v1 #158292 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6NPK
Type: protein
Length: 944 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Solute carrier family 12 (SODIUM/POTASSIUM/CHLORIDE transporter), member 2
UniProt: A0A0G2KGS0
Pockets: 15 · best druggability 0.83

Structure

electron microscopy · 1 distinct chain · 63% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Solute carrier family 12 (SODIUM/POTASSIUM/CHLORIDE transporter), member 2	protein	472	63% helix, 2% strand	A0A0G2KGS0

Pockets

15 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	685	0.83	0.87	55	empty
2	258	0.58	0.79	42	empty
3	178	0.57	0.81	30	empty
4	139	0.49	0.78	24	empty
5	78	0.41	0.78	17	empty

Interfaces

1 interface between chains.

A–B · 738 Å² buried · 1 hydrogen bond · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

6NPK · Structure of the TM domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A0G2KGS0
Elsewhere: RCSB PDB 6NPK · PDBe 6NPK · UniProt A0A0G2KGS0

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