MolNFT v1 · #158266 · protein
Crystal structure of a full length elongation factor G (ef-G) from rickettsia prowazekii
6NOT: “Crystal structure of a full length elongation factor G (ef-G) from rickettsia prowazekii”. X-ray diffraction, 10 pockets (best druggability 0.79). MolNFT v1 #158266 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6NOT
- Type
- protein
- Length
- 1,266 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Elongation factor G
- UniProt
- P41084
- Pockets
- 10 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Elongation factor G | protein | 635 | 30% helix, 35% strand | P41084 |
| B | Elongation factor G | protein | 631 | 30% helix, 35% strand | P41084 |
Pockets
10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1192 | 0.79 | 0.81 | 120 | empty |
| 2 | 558 | 0.76 | 0.83 | 63 | empty |
| 3 | 370 | 0.63 | 0.78 | 65 | empty |
| 4 | 257 | 0.59 | 0.79 | 29 | empty |
| 5 | 127 | 0.52 | 0.81 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 17 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6NOT · Crystal structure of a full length elongation factor G (EF-G) from Rickettsia prowazekii · the same entry in another collection · chain A against A, TM-score 1.00
- P41084 · AlphaFold monomer V2.0 prediction for elongation factor G (P41084) · a predicted model of the same protein · chain B against A, TM-score 0.74
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P41084
- Elsewhere: RCSB PDB 6NOT · PDBe 6NOT · UniProt P41084
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