MolNFT v1 · #158187 · protein

Crystal structure of rat ric-8A G alpha binding domain, "paratone-N immersed"

6NMJ · Resistance to inhibitors of cholinesterase 8 homolog a (C.…: “Crystal structure of rat ric-8A G alpha binding domain, "paratone-N immersed"”. X-ray diffraction, 5 pockets (best druggability 0.83). MolNFT v1 #158187 on GenesisL1: 3D…

PDB: 6NMJ
Type: protein
Length: 813 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Resistance to inhibitors of cholinesterase 8 homolog a (C. elegans)
UniProt: B1H241
Pockets: 5 · best druggability 0.83

Structure

x-ray diffraction · 2 distinct chains · 68% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Resistance to inhibitors of cholinesterase 8 homolog a (C. elegans)	protein	412	69% helix, 2% strand	B1H241
B	Resistance to inhibitors of cholinesterase 8 homolog a (C. elegans)	protein	401	68% helix, 1% strand	B1H241

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	934	0.83	0.85	121	empty
2	76	0.31	0.74	13	empty
3	50	0.29	0.76	14	empty
4	52	0.26	0.74	17	empty
5	52	0.25	0.72	16	empty

Interfaces

1 interface between chains.

A–B · 1751 Å² buried · 30 hydrogen bonds · protein-protein

Compared structures

6NMJ · Crystal Structure of Rat Ric-8A G alpha binding domain, Paratone-N Immersed"" · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B1H241
Elsewhere: RCSB PDB 6NMJ · PDBe 6NMJ · UniProt B1H241

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