MolNFT v1 · #158185 · protein
Crystal structure of rat ric-8A G alpha binding domain
6NMG · Resistance to inhibitors of cholinesterase 8 homolog a (C.…: “Crystal structure of rat ric-8A G alpha binding domain”. X-ray diffraction, 1 ligand (SO4), 7 pockets (best druggability 0.81). MolNFT v1 #158185 on GenesisL1: 3D…
- PDB
- 6NMG
- Type
- protein
- Length
- 843 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Resistance to inhibitors of cholinesterase 8 homolog a (C. elegans)
- UniProt
- B1H241
- Ligands
- SO4
- Pockets
- 7 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 67% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Resistance to inhibitors of cholinesterase 8 homolog a (C. elegans) | protein | 413 | 69% helix, 1% strand | B1H241 |
| B | Resistance to inhibitors of cholinesterase 8 homolog a (C. elegans) | protein | 430 | 65% helix, 1% strand | B1H241 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 668 | 0.81 | 0.86 | 85 | SO4 |
| 2 | 424 | 0.75 | 0.84 | 59 | empty |
| 3 | 171 | 0.46 | 0.76 | 30 | empty |
| 4 | 66 | 0.38 | 0.79 | 13 | empty |
| 5 | 70 | 0.35 | 0.76 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 2079 Ų buried · 28 hydrogen bonds · protein-protein
Compared structures
- 6NMG · Crystal Structure of Rat Ric-8A G alpha binding domain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B1H241
- Elsewhere: RCSB PDB 6NMG · PDBe 6NMG · UniProt B1H241
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