MolNFT v1 · #158099 · protein

Type IV CRISPR associated RNA endonuclease CAS6 - apo form

6NJY · Type IV CRISPR associated CAS6 RNA endonuclease: “Type IV CRISPR associated RNA endonuclease CAS6 - apo form”. X-ray diffraction, 2 ligands (BGC, SO4), 8 pockets (best druggability 0.73). MolNFT v1 #158099 on GenesisL1: 3D…

PDB: 6NJY
Type: protein
Length: 474 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Type IV CRISPR associated CAS6 RNA endonuclease
UniProt: F3ZXK6
Ligands: BGC, SO4
Pockets: 8 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 29% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Type IV CRISPR associated CAS6 RNA endonuclease	protein	237	29% helix, 30% strand	F3ZXK6

Ligands and binding sites

BGC · beta-D-glucopyranose · sugar · 4 copies · chains A, B
SO4 · Sulfate ion · ion · 19 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	777	0.73	0.78	58	empty
2	259	0.59	0.79	36	empty
3	264	0.57	0.78	23	empty
4	246	0.57	0.78	36	empty
5	232	0.55	0.77	23	empty

Interfaces

1 interface between chains.

A–B · 1103 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

6NJY · Type IV CRISPR associated RNA endonuclease Cas6 - apo form · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt F3ZXK6
Elsewhere: RCSB PDB 6NJY · PDBe 6NJY · UniProt F3ZXK6

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