MolNFT v1 · #157901 · protein
Crystal structure of heterotrimeric G-protein alpha subunit GALPHA7 from naegleria fowleri
6NE6: “Crystal structure of heterotrimeric G-protein alpha subunit GALPHA7 from naegleria fowleri”. X-ray diffraction, 1 ligand (NA), 4 pockets (best druggability 0.66). MolNFT v1 #157901 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6NE6
- Type
- protein
- Length
- 327 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- G-protein alpha subunit GALPHA7
- Ligands
- NA
- Pockets
- 4 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 50% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | G-protein alpha subunit GALPHA7 | protein | 327 | 50% helix, 13% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 218 | 0.66 | 0.84 | 38 | empty |
| 2 | 147 | 0.49 | 0.78 | 21 | empty |
| 3 | 139 | 0.45 | 0.77 | 27 | empty |
| 4 | 100 | 0.38 | 0.76 | 17 | EDO |
Compared structures
- 6NE6 · Crystal Structure of heterotrimeric G-protein alpha subunit Galpha7 from Naegleria fowleri · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6NE6 · PDBe 6NE6
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