MolNFT v1 · #157821 · protein
Crystal structure of enolase from legionella pneumophila bound to phosphate and magnesium
6NBM: “Crystal structure of enolase from legionella pneumophila bound to phosphate and magnesium”. X-ray diffraction, 2 ligands (MG, PO4), 6 pockets (best druggability 0.75). MolNFT v1 #157821 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6NBM
- Type
- protein
- Length
- 847 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Enolase
- EC
- 4.2.1.11
- UniProt
- A0A2S6F4U1
- Ligands
- MG, PO4
- Pockets
- 6 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Enolase (EC 4.2.1.11) | protein | 423 | 43% helix, 19% strand | A0A2S6F4U1 |
| B | Enolase (EC 4.2.1.11) | protein | 424 | 43% helix, 19% strand | A0A2S6F4U1 |
Ligands and binding sites
- MG · Magnesium ion · metal · 4 copies · chains A, B
- PO4 · Phosphate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1179 | 0.75 | 0.78 | 60 | empty |
| 2 | 132 | 0.50 | 0.80 | 32 | empty |
| 3 | 148 | 0.50 | 0.79 | 29 | empty |
| 4 | 68 | 0.36 | 0.77 | 18 | empty |
| 5 | 73 | 0.35 | 0.76 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1794 Ų buried · 47 hydrogen bonds · protein-protein
Compared structures
- 6NBM · Crystal structure of enolase from legionella pneumophila bound to phosphate and magnesium · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A2S6F4U1
- Elsewhere: RCSB PDB 6NBM · PDBe 6NBM · UniProt A0A2S6F4U1
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