MolNFT v1 · #157722 · protein

Resistance to inhibitors of cholinesterase 8A (RIC8A) protein

6N86 · Synembryn-a: “Resistance to inhibitors of cholinesterase 8A (RIC8A) protein”. X-ray diffraction, 2 pockets (best druggability 0.58). MolNFT v1 #157722 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6N86
Type: protein
Length: 399 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Synembryn-a
UniProt: Q5E9J8
Pockets: 2 · best druggability 0.58

Structure

x-ray diffraction · 1 distinct chain · 71% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Synembryn-a	protein	399	71% helix, 1% strand	Q5E9J8

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	57	0.58	0.90	14	empty
2	85	0.34	0.75	17	empty

Compared structures

6N86 · Resistance to inhibitors of cholinesterase 8A (Ric8A) protein · the same entry in another collection · chain B against B, TM-score 1.00
Q5E9J8 · AlphaFold monomer V2.0 prediction for synembryn-a (Q5E9J8) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5E9J8
Elsewhere: RCSB PDB 6N86 · PDBe 6N86 · UniProt Q5E9J8

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