MolNFT v1 · #157549 · protein

Crystal structure of the btb domain of human NS1-bp

6N34 · Influenza virus NS1A-binding protein: “Crystal structure of the btb domain of human NS1-bp”. X-ray diffraction, 1 pocket (best druggability 0.78). MolNFT v1 #157549 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6N34
Type: protein
Length: 238 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Influenza virus NS1A-binding protein
UniProt: Q9Y6Y0
Pockets: 1 · best druggability 0.78

Structure

x-ray diffraction · 2 distinct chains · 57% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Influenza virus NS1A-binding protein	protein	119	55% helix, 18% strand	Q9Y6Y0
B	Influenza virus NS1A-binding protein	protein	119	58% helix, 19% strand	Q9Y6Y0

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	126	0.78	0.96	31	empty

Interfaces

1 interface between chains.

A–B · 1888 Å² buried · 21 hydrogen bonds · protein-protein

Compared structures

6N34 · Crystal structure of the BTB domain of Human NS1-BP · the same entry in another collection · chain A against A, TM-score 1.00
Q9Y6Y0 · AlphaFold monomer V2.0 prediction for influenza virus NS1A-binding protein (Q9Y6Y0) · a predicted model of the same protein · chain B against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y6Y0
Elsewhere: RCSB PDB 6N34 · PDBe 6N34 · UniProt Q9Y6Y0

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