MolNFT v1 · #157454 · protein

Zebrafish betaglycan orphan domain structure from orthorhombic crystal form

6MZP · Transforming growth factor beta receptor III: “Zebrafish betaglycan orphan domain structure from orthorhombic crystal form”. X-ray diffraction, 6 pockets (best druggability 0.72). MolNFT v1 #157454 on GenesisL1: 3D structure…

PDB: 6MZP
Type: protein
Length: 609 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transforming growth factor beta receptor III
UniProt: A0A0H3UK16
Pockets: 6 · best druggability 0.72

Structure

x-ray diffraction · 2 distinct chains · 9% helix, 47% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transforming growth factor beta receptor III	protein	314	9% helix, 47% strand	A0A0H3UK16
B	Transforming growth factor beta receptor III	protein	295	8% helix, 47% strand	A0A0H3UK16

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	620	0.72	0.79	64	empty
2	352	0.70	0.83	48	empty
3	78	0.37	0.77	14	empty
4	67	0.35	0.76	16	empty
5	71	0.32	0.74	14	empty

Interfaces

1 interface between chains.

A–B · 838 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

6MZP · Zebrafish betaglycan orphan domain structure from orthorhombic crystal form · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A0H3UK16
Elsewhere: RCSB PDB 6MZP · PDBe 6MZP · UniProt A0A0H3UK16

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