Crystal structure of human scribble PDZ1 domain in complex with internal PDZ binding motif of src homology 3 domain-containing guanine nucleotide exchange factor (sgef)

Structure

x-ray diffraction · 2 distinct chains · 13% helix, 40% strand (DSSP).

Ligands and binding sites

• ACE · Acetyl group · ligand · chains B
• NH2 · Amino group · ion · chains A, B
• FMT · Formic acid · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 540 Ų buried · 17 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 covalent (covalent ligand).

Compared structures

• 6MYE · Crystal structure of human Scribble PDZ1 domain in complex with internal PDZ binding… · the same entry in another collection · chain A against A, TM-score 1.00
• Q14160 · AlphaFold monomer V2.0 prediction for protein scribble homolog (Q14160) · a predicted model of the same protein · chain A against A, TM-score 0.96
• Q96DR7 · AlphaFold monomer V2.0 prediction for rho guanine nucleotide exchange factor 26 (Q96DR7) · a predicted model of the same protein · chain B against A, TM-score 0.32

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q14160
• Every structure of UniProt Q96DR7
• Elsewhere: RCSB PDB 6MYE · PDBe 6MYE · UniProt Q14160 · UniProt Q96DR7