MolNFT v1 · #157332 · protein
Lasr lbd L130F:3OC14HSL complex
6MVM · Transcriptional regulator lasr: “Lasr lbd L130F:3OC14HSL complex”. X-ray diffraction, 1 ligand (K4G), 3 pockets (best druggability 0.79). MolNFT v1 #157332 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6MVM
- Type
- protein
- Length
- 324 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcriptional regulator lasr
- UniProt
- A0A0H2Z901
- Ligands
- K4G
- Pockets
- 3 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 53% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Transcriptional regulator lasr | protein | 162 | 53% helix, 17% strand | A0A0H2Z901 |
Ligands and binding sites
- K4G · 3-oxo-N-[(3S)-2-oxooxolan-3-yl]tetradecanamide · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 158 | 0.79 | 0.95 | 28 | K4G |
| 2 | 229 | 0.78 | 0.91 | 34 | K4G |
| 3 | 187 | 0.48 | 0.76 | 29 | empty |
Interfaces
1 interface between chains.
- A–B · 828 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 6MVM · LasR LBD L130F:3OC14HSL complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0H2Z901
- Elsewhere: RCSB PDB 6MVM · PDBe 6MVM · UniProt A0A0H2Z901
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