MolNFT v1 · #157299 · protein
Structure of HRPN10 bound to UBQLN2 ubl
6MUN · 26S proteasome non-ATPase regulatory subunit 4: “Structure of HRPN10 bound to UBQLN2 ubl”. Solution nmr, 1 pocket (best druggability 0.35). MolNFT v1 #157299 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6MUN
- Type
- protein
- Length
- 267 residues
- Chains
- 3
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 26S proteasome non-ATPase regulatory subunit 4; Ubiquilin-2
- UniProt
- P55036, Q9UHD9
- Pockets
- 1 · best druggability 0.35
Structure
solution nmr · 2 distinct chains · 47% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 26S proteasome non-ATPase regulatory subunit 4 | protein | 111 | 65% helix, 0% strand | P55036 |
| B, C | Ubiquilin-2 | protein | 78 | 21% helix, 40% strand | Q9UHD9 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 77 | 0.35 | 0.76 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–B · 560 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 410 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 35 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6MUN · Structure of hRpn10 bound to UBQLN2 UBL · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UHD9 · AlphaFold monomer V2.0 prediction for ubiquilin-2 (Q9UHD9) · a predicted model of the same protein · chain B against A, TM-score 0.90
- P55036 · AlphaFold monomer V2.0 prediction for 26S proteasome non-ATPase regulatory subunit 4… · a predicted model of the same protein · chain A against A, TM-score 0.41
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P55036
- Every structure of UniProt Q9UHD9
- Elsewhere: RCSB PDB 6MUN · PDBe 6MUN · UniProt P55036 · UniProt Q9UHD9
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