MolNFT v1 · #157275 · protein

Crystal structure of a human anti-zikv-denv neutralizing antibody MZ4 isolated following zpiv vaccination

6MTY · MZ4 heavy chain: “Crystal structure of a human anti-zikv-denv neutralizing antibody MZ4 isolated following zpiv vaccination”. X-ray diffraction, 5 pockets (best druggability 0.71). MolNFT v1 #157275 on GenesisL1: 3D structure…

PDB: 6MTY
Type: protein
Length: 431 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: MZ4 heavy chain; MZ4 light chain
Pockets: 5 · best druggability 0.71

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	MZ4 heavy chain	protein	217	4% helix, 49% strand	—
L	MZ4 light chain	protein	214	7% helix, 50% strand	—

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	823	0.71	0.77	67	empty
2	88	0.38	0.77	20	empty
3	118	0.36	0.73	32	empty
4	63	0.33	0.76	17	empty
5	51	0.28	0.75	13	empty

Interfaces

1 interface between chains.

H–L · 1936 Å² buried · 18 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

6MTY · Crystal structure of a human anti-ZIKV-DENV neutralizing antibody MZ4 isolated following… · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6MTY · PDBe 6MTY

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