MolNFT v1 · #157268 · protein
Crystal structure of VRC43.01 Fab
6MTR · Antibody VRC43.01 Fab heavy chain: “Crystal structure of VRC43.01 Fab”. X-ray diffraction, 2 pockets (best druggability 0.63). MolNFT v1 #157268 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6MTR
- Type
- protein
- Length
- 431 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Antibody VRC43.01 Fab heavy chain; Antibody VRC43.01 Fab light chain
- Pockets
- 2 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 8% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Antibody VRC43.01 Fab heavy chain | protein | 221 | 8% helix, 50% strand | — |
| L | Antibody VRC43.01 Fab light chain | protein | 210 | 8% helix, 52% strand | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 529 | 0.63 | 0.76 | 68 | empty |
| 2 | 66 | 0.30 | 0.74 | 21 | empty |
Interfaces
1 interface between chains.
- H–L · 1750 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6MTR · Crystal structure of VRC43.01 Fab · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6MTR · PDBe 6MTR
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