MolNFT v1 · #157257 · protein
A single reactive noncanonical amino acid is able to dramatically stabilize protein structure
6MTG · Homoserine O-succinyltransferase: “A single reactive noncanonical amino acid is able to dramatically stabilize protein structure”. X-ray diffraction, 9 pockets (best druggability 0.67). MolNFT v1 #157257 on GenesisL1: 3D structure…
- PDB
- 6MTG
- Type
- protein
- Length
- 583 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Homoserine O-succinyltransferase
- EC
- 2.3.1.46
- UniProt
- P07623
- Pockets
- 9 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Homoserine O-succinyltransferase (EC 2.3.1.46) | protein | 291 | 33% helix, 25% strand | P07623 |
| B | Homoserine O-succinyltransferase (EC 2.3.1.46) | protein | 292 | 32% helix, 25% strand | P07623 |
Ligands and binding sites
- FMT · Formic acid · additive · 5 copies · chains A, B
- PEG · Di(hydroxyethyl)ether · additive · 2 copies · chains A, B
- GOL · Glycerol · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 317 | 0.67 | 0.82 | 47 | empty |
| 2 | 187 | 0.65 | 0.85 | 27 | PEG |
| 3 | 176 | 0.64 | 0.85 | 29 | empty |
| 4 | 241 | 0.60 | 0.80 | 26 | FMT |
| 5 | 164 | 0.56 | 0.81 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 2236 Ų buried · 35 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (oxidation).
Compared structures
- 6MTG · A Single Reactive Noncanonical Amino Acid is Able to Dramatically Stabilize Protein… · the same entry in another collection · chain A against A, TM-score 1.00
- P07623 · AlphaFold monomer V2.0 prediction for homoserine O-succinyltransferase (P07623) · a predicted model of the same protein · chain A against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07623
- Elsewhere: RCSB PDB 6MTG · PDBe 6MTG · UniProt P07623
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