MolNFT v1 · #157252 · protein
Phlebotomus duboscqi salivary D7 protein, selenomethionine derivative
6MT7 · 26.7 kda salivary protein: “Phlebotomus duboscqi salivary D7 protein, selenomethionine derivative”. X-ray diffraction, 1 ligand (TRT), 9 pockets (best druggability 0.77). MolNFT v1 #157252 on GenesisL1: 3D structure, binding sites…
- PDB
- 6MT7
- Type
- protein
- Length
- 460 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 26.7 kda salivary protein
- UniProt
- Q06KA2
- Ligands
- TRT
- Pockets
- 9 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 54% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | 26.7 kda salivary protein | protein | 230 | 54% helix, 3% strand | Q06KA2 |
Ligands and binding sites
- TRT · Fragment of triton X-100 · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 999 | 0.77 | 0.79 | 54 | empty |
| 2 | 249 | 0.76 | 0.89 | 34 | TRT |
| 3 | 274 | 0.75 | 0.88 | 28 | TRT |
| 4 | 70 | 0.59 | 0.89 | 20 | empty |
| 5 | 62 | 0.58 | 0.90 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 280 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide, 6 modified (disulfide, engineered).
Compared structures
- 6MT7 · Phlebotomus duboscqi salivary D7 protein, selenomethionine derivative · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q06KA2
- Elsewhere: RCSB PDB 6MT7 · PDBe 6MT7 · UniProt Q06KA2
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