MolNFT v1 · #157218 · protein
SIALIDASE26 apo
6MRX: “SIALIDASE26 apo”. X-ray diffraction, 20 pockets (best druggability 0.76). MolNFT v1 #157218 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6MRX
- Type
- protein
- Length
- 2,087 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SIALIDASE26
- Pockets
- 20 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | SIALIDASE26 | protein | 522 | 6% helix, 45% strand | — |
| D | SIALIDASE26 | protein | 521 | 6% helix, 45% strand | — |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1161 | 0.76 | 0.78 | 96 | empty |
| 2 | 822 | 0.72 | 0.77 | 90 | empty |
| 3 | 328 | 0.67 | 0.82 | 26 | empty |
| 4 | 318 | 0.66 | 0.82 | 32 | empty |
| 5 | 349 | 0.66 | 0.81 | 32 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1649 Ų buried · 30 hydrogen bonds · protein-protein
- C–D · 1646 Ų buried · 30 hydrogen bonds · protein-protein
- B–C · 688 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6MRX · Sialidase26 apo · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6MRX · PDBe 6MRX
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