MolNFT v1 · #157180 · protein

PL5, synthetic transmembrane domain variant of human phospholamban

6MQU · PL5, designed tm pentamer: “PL5, synthetic transmembrane domain variant of human phospholamban”. X-ray diffraction, 4 pockets (best druggability 0.81). MolNFT v1 #157180 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6MQU
Type: protein
Length: 269 residues
Chains: 10
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: PL5, designed tm pentamer
Pockets: 4 · best druggability 0.81

Structure

x-ray diffraction · 3 distinct chains · 90% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, D, F, G, H, I	PL5, designed tm pentamer	protein	27	93% helix, 0% strand	—
C	PL5, designed tm pentamer	protein	28	93% helix, 0% strand	—
E, J	PL5, designed tm pentamer	protein	26	85% helix, 0% strand	—

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	245	0.81	0.91	35	empty
2	278	0.79	0.89	38	empty
3	94	0.37	0.75	14	empty
4	85	0.35	0.74	10	empty

Interfaces

14 interfaces between chains.

F–J · 653 Å² buried · 2 hydrogen bonds · protein-protein
A–E · 641 Å² buried · 2 hydrogen bonds · protein-protein
C–D · 625 Å² buried · 2 hydrogen bonds · protein-protein
H–I · 620 Å² buried · 2 hydrogen bonds · protein-protein
D–E · 615 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6MQU · PL5, synthetic transmembrane domain variant of human phospholamban · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6MQU · PDBe 6MQU

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