MolNFT v1 · #157167 · protein
Crystal structure of 4-hydroxy-tetrahydrodipicolinate synthase (htpa synthase) from burkholderia mallei
6MQH: “Crystal structure of 4-hydroxy-tetrahydrodipicolinate synthase (htpa synthase) from burkholderia mallei”. X-ray diffraction, 3 pockets (best druggability 0.75). MolNFT v1 #157167 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 6MQH
- Type
- protein
- Length
- 586 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 4-hydroxy-tetrahydrodipicolinate synthase
- EC
- 4.3.3.7
- UniProt
- A0A0H2WFM6
- Pockets
- 3 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 49% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | 4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7) | protein | 293 | 49% helix, 13% strand | A0A0H2WFM6 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 411 | 0.75 | 0.85 | 59 | empty |
| 2 | 124 | 0.50 | 0.80 | 25 | empty |
| 3 | 136 | 0.49 | 0.79 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 1464 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 6MQH · Crystal structure of 4-hydroxy-tetrahydrodipicolinate synthase (HTPA synthase) from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0H2WFM6
- Elsewhere: RCSB PDB 6MQH · PDBe 6MQH · UniProt A0A0H2WFM6
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