MolNFT v1 · #157157 · protein

Crystal structure of CLASP1 TOG2 domain at 1.78A resolution

6MQ7 · Clip-associating protein 1: “Crystal structure of CLASP1 TOG2 domain at 1.78A resolution”. X-ray diffraction, 3 pockets (best druggability 0.67). MolNFT v1 #157157 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6MQ7
Type: protein
Length: 488 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Clip-associating protein 1
UniProt: Q7Z460
Pockets: 3 · best druggability 0.67

Structure

x-ray diffraction · 1 distinct chain · 77% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Clip-associating protein 1	protein	244	77% helix, 0% strand	Q7Z460

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	407	0.67	0.80	54	empty
2	368	0.55	0.74	41	empty
3	55	0.27	0.74	15	empty

Interfaces

1 interface between chains.

A–B · 895 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

6MQ7 · Crystal structure of CLASP1 TOG2 domain at 1.78A resolution · the same entry in another collection · chain A against A, TM-score 1.00
Q7Z460 · AlphaFold monomer V2.0 prediction for clip-associating protein 1 (Q7Z460) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7Z460
Elsewhere: RCSB PDB 6MQ7 · PDBe 6MQ7 · UniProt Q7Z460

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