MolNFT v1 · #157131 · protein

Crystal structure of E257A mutant of BLMAN5B

6MPC: “Crystal structure of E257A mutant of BLMAN5B”. X-ray diffraction, 9 pockets (best druggability 0.83). MolNFT v1 #157131 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6MPC
Type: protein
Length: 836 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: BLMAN5B
UniProt: B3DQP5
Pockets: 9 · best druggability 0.83

Structure

x-ray diffraction · 2 distinct chains · 42% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	BLMAN5B	protein	418	42% helix, 15% strand	B3DQP5
B	BLMAN5B	protein	418	42% helix, 15% strand	B3DQP5

Pockets

9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	237	0.83	0.95	49	empty
2	303	0.64	0.80	29	empty
3	271	0.62	0.80	27	empty
4	88	0.43	0.80	27	empty
5	54	0.41	0.82	20	empty

Interfaces

1 interface between chains.

A–B · 1759 Å² buried · 34 hydrogen bonds · protein-protein

Compared structures

6MPC · Crystal structure of E257A mutant of BlMan5B · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B3DQP5
Elsewhere: RCSB PDB 6MPC · PDBe 6MPC · UniProt B3DQP5

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