MolNFT v1 · #157070 · protein
NMR solution structures of second bromodomain of BRD4 with FOXO3A peptide
6MNL: “NMR solution structures of second bromodomain of BRD4 with FOXO3A peptide”. Solution nmr. MolNFT v1 #157070 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6MNL
- Type
- protein
- Length
- 144 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- FOXO3A peptide; Bromodomain-containing protein 4
- UniProt
- O60885
Structure
solution nmr · 2 distinct chains · 49% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | FOXO3A peptide | protein | 16 | 0% helix, 0% strand | — |
| B | Bromodomain-containing protein 4 | protein | 128 | 55% helix, 0% strand | O60885 |
Interfaces
1 interface between chains.
- A–B · 637 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (acetylation).
Compared structures
- 6MNL · NMR solution structures of second bromodomain of BRD4 with FOXO3a peptide · the same entry in another collection · chain A against A, TM-score 1.00
- O60885 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (O60885) · a predicted model of the same protein · chain B against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60885
- Elsewhere: RCSB PDB 6MNL · PDBe 6MNL · UniProt O60885
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