MolNFT v1 · #157044 · protein
Carbon regulatory pii-like protein sbtb from cyanobium sp. 7001 bound to camp
6MMQ: “Carbon regulatory pii-like protein sbtb from cyanobium sp. 7001 bound to camp”. X-ray diffraction, 1 ligand (CMP), 10 pockets (best druggability 0.60). MolNFT v1 #157044 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6MMQ
- Type
- protein
- Length
- 510 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Carbon regulatory pii-like protein sbtb
- UniProt
- B5II98
- Ligands
- CMP
- Pockets
- 10 · best druggability 0.60
Structure
x-ray diffraction · 5 distinct chains · 33% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, E | Carbon regulatory pii-like protein sbtb | protein | 82 | 35% helix, 44% strand | B5II98 |
| B | Carbon regulatory pii-like protein sbtb | protein | 90 | 31% helix, 43% strand | B5II98 |
| D | Carbon regulatory pii-like protein sbtb | protein | 84 | 33% helix, 42% strand | B5II98 |
| C | Carbon regulatory pii-like protein sbtb | protein | 87 | 33% helix, 43% strand | B5II98 |
| F | Carbon regulatory pii-like protein sbtb | protein | 85 | 34% helix, 44% strand | B5II98 |
Ligands and binding sites
- CMP · Adenosine-3',5'-cyclic-monophosphate · ligand · 6 copies · chains A, D, B, C, F, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 252 | 0.60 | 0.79 | 32 | empty |
| 2 | 97 | 0.55 | 0.85 | 30 | empty |
| 3 | 135 | 0.54 | 0.81 | 31 | empty |
| 4 | 232 | 0.53 | 0.77 | 30 | CMP |
| 5 | 125 | 0.49 | 0.80 | 24 | CMP |
Interfaces
9 interfaces between chains.
- A–B · 818 Ų buried · 18 hydrogen bonds · protein-protein
- C–E · 746 Ų buried · 16 hydrogen bonds · protein-protein
- C–F · 739 Ų buried · 16 hydrogen bonds · protein-protein
- B–D · 709 Ų buried · 16 hydrogen bonds · protein-protein
- E–F · 694 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 6MMQ · Carbon regulatory PII-like protein SbtB from Cyanobium sp. 7001 bound to cAMP · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B5II98
- Elsewhere: RCSB PDB 6MMQ · PDBe 6MMQ · UniProt B5II98
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.