MolNFT v1 · #157021 · protein
Structure of the cysteine-rich region from human EHMT2
6MM1 · Histone-lysine N-methyltransferase EHMT2: “Structure of the cysteine-rich region from human EHMT2”. X-ray diffraction, 1 ligand (ZN), 1 pocket (best druggability 0.74). MolNFT v1 #157021 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6MM1
- Type
- protein
- Length
- 534 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone-lysine N-methyltransferase EHMT2
- EC
- 2.1.1.-, 2.1.1.43
- UniProt
- Q96KQ7
- Ligands
- ZN
- Pockets
- 1 · best druggability 0.74
Structure
x-ray diffraction · 4 distinct chains · 15% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-, 2.1.1.43) | protein | 133 | 16% helix, 34% strand | Q96KQ7 |
| B | Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-, 2.1.1.43) | protein | 134 | 15% helix, 29% strand | Q96KQ7 |
| C | Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-, 2.1.1.43) | protein | 132 | 14% helix, 28% strand | Q96KQ7 |
| D | Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-, 2.1.1.43) | protein | 135 | 16% helix, 28% strand | Q96KQ7 |
Ligands and binding sites
- ZN · Zinc ion · metal · 16 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 829 | 0.74 | 0.79 | 100 | empty |
Interfaces
5 interfaces between chains.
- A–B · 474 Ų buried · 11 hydrogen bonds · protein-protein
- B–D · 359 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 357 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 213 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 50 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6MM1 · Structure of the cysteine-rich region from human EHMT2 · the same entry in another collection · chain D against D, TM-score 1.00
- Q96KQ7 · AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase EHMT2 (Q96KQ7) · a predicted model of the same protein · chain C against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96KQ7
- Elsewhere: RCSB PDB 6MM1 · PDBe 6MM1 · UniProt Q96KQ7
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