MolNFT v1 · #15688 · protein

A new paradigm for tumor necrosis factor signalling

1NCF · Tumor necrosis factor receptor: “A new paradigm for tumor necrosis factor signalling”. X-ray diffraction, 1 pocket (best druggability 0.30). MolNFT v1 #15688 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1NCF
Type: protein
Length: 282 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tumor necrosis factor receptor
UniProt: P19438
Pockets: 1 · best druggability 0.30

Structure

x-ray diffraction · 2 distinct chains · 2% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tumor necrosis factor receptor	protein	140	2% helix, 42% strand	P19438
B	Tumor necrosis factor receptor	protein	142	2% helix, 39% strand	P19438

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	60	0.30	0.75	15	empty

Interfaces

1 interface between chains.

A–B · 1099 Å² buried · 17 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 20 disulfide (disulfide).

Compared structures

1NCF · A new paradigm for tumor necrosis factor signalling · the same entry in another collection · chain A against A, TM-score 1.00
P19438 · AlphaFold monomer V2.0 prediction for tumor necrosis factor receptor superfamily member… · a predicted model of the same protein · chain B against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P19438
Elsewhere: RCSB PDB 1NCF · PDBe 1NCF · UniProt P19438

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