MolNFT v1 · #156840 · protein

Structure of mechanically activated ion channel OSCA1.2 in nanodisc

6MGV · Calcium permeable stress-gated cation channel 1: “Structure of mechanically activated ion channel OSCA1.2 in nanodisc”. Electron microscopy, 14 pockets (best druggability 0.74). MolNFT v1 #156840 on GenesisL1: 3D structure, binding…

PDB: 6MGV
Type: protein
Length: 1,268 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Calcium permeable stress-gated cation channel 1
UniProt: Q5XEZ5
Pockets: 14 · best druggability 0.74

Structure

electron microscopy · 1 distinct chain · 68% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Calcium permeable stress-gated cation channel 1	protein	634	68% helix, 4% strand	Q5XEZ5

Pockets

14 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	694	0.74	0.80	68	empty
2	620	0.74	0.81	52	empty
3	554	0.66	0.77	60	empty
4	542	0.64	0.76	59	empty
5	103	0.44	0.79	19	empty

Interfaces

1 interface between chains.

A–B · 1346 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

6MGV · Structure of mechanically activated ion channel OSCA1.2 in nanodisc · the same entry in another collection · chain A against A, TM-score 1.00
Q5XEZ5 · AlphaFold monomer V2.0 prediction for calcium permeable stress-gated cation channel 1… · a predicted model of the same protein · chain B against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5XEZ5
Elsewhere: RCSB PDB 6MGV · PDBe 6MGV · UniProt Q5XEZ5

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