MolNFT v1 · #156695 · protein + RNA
Solution structure of 7SK stem-loop 1 with HIV-1 tat RNA binding domain
6MCF · 7SK stem-loop 1 RNA: “Solution structure of 7SK stem-loop 1 with HIV-1 tat RNA binding domain”. Solution nmr, 3 pockets (best druggability 0.64). MolNFT v1 #156695 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6MCF
- Type
- protein + RNA
- Length
- 74 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 7SK stem-loop 1 RNA; Protein tat
- UniProt
- P04608
- Pockets
- 3 · best druggability 0.64
Structure
solution nmr · 2 distinct chains · 0% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 7SK stem-loop 1 RNA | rna | 57 | — | — |
| B | Protein tat | protein | 17 | 0% helix, 12% strand | P04608 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 421 | 0.64 | 0.79 | 25 | empty |
| 2 | 53 | 0.37 | 0.81 | 14 | empty |
| 3 | 60 | 0.27 | 0.74 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1353 Ų buried · 48 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 2 modified (nucleotide modification).
Compared structures
- 6MCF · Solution structure of 7SK stem-loop 1 with HIV-1 Tat RNA Binding Domain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04608
- Elsewhere: RCSB PDB 6MCF · PDBe 6MCF · UniProt P04608
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