MolNFT v1 · #156694 · protein + RNA
Solution structure of HIV-1 tar with tat RNA binding domain
6MCE · Tar RNA: “Solution structure of HIV-1 tar with tat RNA binding domain”. Solution nmr, 2 pockets (best druggability 0.40). MolNFT v1 #156694 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6MCE
- Type
- protein + RNA
- Length
- 47 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tar RNA; Protein tat
- UniProt
- P04608
- Pockets
- 2 · best druggability 0.40
Structure
solution nmr · 2 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tar RNA | rna | 30 | — | — |
| B | Protein tat | protein | 17 | 0% helix, 0% strand | P04608 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 58 | 0.40 | 0.82 | 12 | empty |
| 2 | 91 | 0.32 | 0.73 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1091 Ų buried · 42 hydrogen bonds · protein-nucleic
Compared structures
- 6MCE · Solution structure of HIV-1 TAR with Tat RNA Binding Domain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04608
- Elsewhere: RCSB PDB 6MCE · PDBe 6MCE · UniProt P04608
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