MolNFT v1 · #156681 · protein

Structure of transcription factor

6MBZ · Signal transducer and activator of transcription 5B: “Structure of transcription factor”. X-ray diffraction, 10 pockets (best druggability 0.65). MolNFT v1 #156681 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6MBZ
Type: protein
Length: 1,058 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Signal transducer and activator of transcription 5B
UniProt: P51692
Pockets: 10 · best druggability 0.65

Structure

x-ray diffraction · 2 distinct chains · 51% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Signal transducer and activator of transcription 5B	protein	536	51% helix, 15% strand	P51692
B	Signal transducer and activator of transcription 5B	protein	522	50% helix, 16% strand	P51692

Pockets

10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	406	0.65	0.78	32	empty
2	392	0.65	0.79	35	empty
3	125	0.57	0.84	28	empty
4	63	0.55	0.87	22	empty
5	155	0.52	0.79	24	empty

Interfaces

1 interface between chains.

A–B · 21 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6MBZ · Structure of Transcription Factor · the same entry in another collection · chain A against A, TM-score 1.00
P51692 · AlphaFold monomer V2.0 prediction for signal transducer and activator of transcription 5B… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P51692
Elsewhere: RCSB PDB 6MBZ · PDBe 6MBZ · UniProt P51692

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