MolNFT v1 · #156678 · protein

Structure of transcription factor

6MBW · Signal transducer and activator of transcription 5B: “Structure of transcription factor”. X-ray diffraction, 11 pockets (best druggability 0.68). MolNFT v1 #156678 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6MBW
Type: protein
Length: 1,047 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Signal transducer and activator of transcription 5B
UniProt: P51692
Pockets: 11 · best druggability 0.68

Structure

x-ray diffraction · 2 distinct chains · 50% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Signal transducer and activator of transcription 5B	protein	524	50% helix, 15% strand	P51692
B	Signal transducer and activator of transcription 5B	protein	523	50% helix, 14% strand	P51692

Pockets

11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	177	0.68	0.87	35	empty
2	87	0.68	0.93	30	empty
3	421	0.65	0.78	35	empty
4	409	0.64	0.78	36	empty
5	234	0.62	0.81	43	empty

Compared structures

6MBW · Structure of Transcription Factor · the same entry in another collection · chain A against A, TM-score 1.00
P51692 · AlphaFold monomer V2.0 prediction for signal transducer and activator of transcription 5B… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P51692
Elsewhere: RCSB PDB 6MBW · PDBe 6MBW · UniProt P51692

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