MolNFT v1 · #156564 · protein

Crystal structure of inward rectifier KIR2.2 force open mutant

6M86 · ATP-sensitive inward rectifier potassium channel 12: “Crystal structure of inward rectifier KIR2.2 force open mutant”. X-ray diffraction, 1 ligand (K), 2 pockets (best druggability 0.45). MolNFT v1 #156564 on GenesisL1: 3D…

PDB: 6M86
Type: protein
Length: 322 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ATP-sensitive inward rectifier potassium channel 12
UniProt: F1NHE9
Ligands: K
Pockets: 2 · best druggability 0.45

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ATP-sensitive inward rectifier potassium channel 12	protein	322	30% helix, 26% strand	F1NHE9

Ligands and binding sites

K · Potassium ion · metal · 5 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	115	0.45	0.78	20	empty
2	74	0.34	0.75	21	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

6M86 · Crystal Structure of Inward Rectifier Kir2.2 Force Open Mutant · the same entry in another collection · chain A against A, TM-score 1.00
F1NHE9 · AlphaFold monomer V2.0 prediction for ATP-sensitive inward rectifier potassium channel 12… · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt F1NHE9
Elsewhere: RCSB PDB 6M86 · PDBe 6M86 · UniProt F1NHE9

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