Crystal structure of CKIR2.2 force open mutant in complex with PI(4, 5)P2

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 27% strand (DSSP).

Ligands and binding sites

• PIO · [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2, 3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate · ligand · chains A
• K · Potassium ion · metal · 6 copies · chains A
• LMT · Dodecyl-beta-D-maltoside · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

• 6M84 · Crystal structure of cKir2.2 force open mutant in complex with PI(4,5)P2 · the same entry in another collection · chain A against A, TM-score 1.00
• F1NHE9 · AlphaFold monomer V2.0 prediction for ATP-sensitive inward rectifier potassium channel 12… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt F1NHE9
• Elsewhere: RCSB PDB 6M84 · PDBe 6M84 · UniProt F1NHE9