MolNFT v1 · #156534 · protein
Aromatic interactions drive the coupled folding and binding of the intrinsically disordered sesbania mosaic virus vpg protein
6M78 · Polyprotein: “Aromatic interactions drive the coupled folding and binding of the intrinsically disordered sesbania mosaic…”. Solution nmr, 2 pockets (best druggability 0.46). MolNFT v1 #156534 on GenesisL1: 3D structure, binding…
- PDB
- 6M78
- Type
- protein
- Length
- 248 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Polyprotein
- UniProt
- Q9EB08
- Pockets
- 2 · best druggability 0.46
Structure
solution nmr · 2 distinct chains · 8% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Polyprotein | protein | 191 | 8% helix, 43% strand | Q9EB08 |
| B | Polyprotein | protein | 57 | 7% helix, 21% strand | Q9EB08 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 113 | 0.46 | 0.78 | 22 | empty |
| 2 | 80 | 0.32 | 0.74 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 727 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6M78 · Aromatic interactions drive the coupled folding and binding of the intrinsically… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9EB08
- Elsewhere: RCSB PDB 6M78 · PDBe 6M78 · UniProt Q9EB08
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