MolNFT v1 · #156526 · protein
A de novo designed transmembrane nanopore, TMH4C4
6M6Z: “A de novo designed transmembrane nanopore, TMH4C4”. Electron microscopy, 20 pockets (best druggability 0.73). MolNFT v1 #156526 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6M6Z
- Type
- protein
- Length
- 812 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TMH4C4
- Pockets
- 20 · best druggability 0.73
Structure
electron microscopy · 1 distinct chain · 92% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | TMH4C4 | protein | 203 | 92% helix, 0% strand | — |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 441 | 0.73 | 0.83 | 62 | empty |
| 2 | 660 | 0.68 | 0.76 | 92 | empty |
| 3 | 206 | 0.65 | 0.84 | 39 | empty |
| 4 | 319 | 0.62 | 0.78 | 38 | empty |
| 5 | 471 | 0.62 | 0.75 | 50 | empty |
Interfaces
4 interfaces between chains.
- A–D · 1486 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 1483 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 1395 Ų buried · 6 hydrogen bonds · protein-protein
- C–D · 1367 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 6M6Z · A de novo designed transmembrane nanopore, TMH4C4 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6M6Z · PDBe 6M6Z
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