MolNFT v1 · #156506 · protein
Solution structure of the core domain of fibroblast growth factor 21 (FGF21)
6M6E: “Solution structure of the core domain of fibroblast growth factor 21 (FGF21)”. Solution nmr, 2 pockets (best druggability 0.30). MolNFT v1 #156506 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6M6E
- Type
- protein
- Length
- 128 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fibroblast growth factor 21
- UniProt
- Q9NSA1
- Pockets
- 2 · best druggability 0.30
Structure
solution nmr · 1 distinct chain · 9% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fibroblast growth factor 21 | protein | 128 | 9% helix, 41% strand | Q9NSA1 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 62 | 0.30 | 0.75 | 20 | empty |
| 2 | 56 | 0.27 | 0.74 | 15 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6M6E · Solution structure of the core domain of Fibroblast growth factor 21 (FGF21) · the same entry in another collection · chain A against A, TM-score 1.00
- Q9NSA1 · AlphaFold monomer V2.0 prediction for fibroblast growth factor 21 (Q9NSA1) · a predicted model of the same protein · chain A against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NSA1
- Elsewhere: RCSB PDB 6M6E · PDBe 6M6E · UniProt Q9NSA1
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