MolNFT v1 · #156474 · protein
Crystal structure of hink, a lysr family transcriptional regulator from pseudomonas aeruginosa
6M5F · Probable transcriptional regulator: “Crystal structure of hink, a lysr family transcriptional regulator from pseudomonas aeruginosa”. X-ray diffraction, 14 pockets (best druggability 0.84). MolNFT v1 #156474 on GenesisL1: 3D…
- PDB
- 6M5F
- Type
- protein
- Length
- 1,156 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable transcriptional regulator
- UniProt
- Q9I6S0
- Pockets
- 14 · best druggability 0.84
Structure
x-ray diffraction · 4 distinct chains · 42% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Probable transcriptional regulator | protein | 286 | 43% helix, 21% strand | Q9I6S0 |
| B | Probable transcriptional regulator | protein | 293 | 41% helix, 20% strand | Q9I6S0 |
| C | Probable transcriptional regulator | protein | 287 | 41% helix, 22% strand | Q9I6S0 |
| D | Probable transcriptional regulator | protein | 290 | 41% helix, 21% strand | Q9I6S0 |
Pockets
14 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1107 | 0.84 | 0.85 | 102 | empty |
| 2 | 1073 | 0.78 | 0.80 | 92 | empty |
| 3 | 1036 | 0.75 | 0.78 | 96 | empty |
| 4 | 75 | 0.64 | 0.91 | 22 | empty |
| 5 | 187 | 0.62 | 0.83 | 28 | empty |
Interfaces
6 interfaces between chains.
- A–C · 1717 Ų buried · 15 hydrogen bonds · protein-protein
- B–D · 1656 Ų buried · 14 hydrogen bonds · protein-protein
- B–C · 1499 Ų buried · 11 hydrogen bonds · protein-protein
- A–D · 1269 Ų buried · 15 hydrogen bonds · protein-protein
- C–D · 1029 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 6M5F · Crystal structure of HinK, a LysR family transcriptional regulator from Pseudomonas… · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9I6S0
- Elsewhere: RCSB PDB 6M5F · PDBe 6M5F · UniProt Q9I6S0
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