MolNFT v1 · #156423 · protein
Crystal structure of ANKB/BETA4-spectrin complex
6M3Q · Ankyrin-2: “Crystal structure of ANKB/BETA4-spectrin complex”. X-ray diffraction, 11 pockets (best druggability 0.69). MolNFT v1 #156423 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6M3Q
- Type
- protein
- Length
- 754 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ankyrin-2; Spectrin beta chain
- UniProt
- Q01484, Q8VIE5
- Pockets
- 11 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E | Ankyrin-2 | protein | 453 | 9% helix, 43% strand | Q01484 |
| F | Spectrin beta chain | protein | 301 | 89% helix, 0% strand | Q8VIE5 |
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 54 | 0.69 | 0.97 | 18 | empty |
| 2 | 458 | 0.63 | 0.77 | 52 | empty |
| 3 | 71 | 0.52 | 0.85 | 19 | empty |
| 4 | 179 | 0.52 | 0.78 | 26 | empty |
| 5 | 146 | 0.43 | 0.75 | 20 | empty |
Interfaces
1 interface between chains.
- E–F · 1019 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 6M3Q · Crystal structure of AnkB/beta4-spectrin complex · the same entry in another collection · chain E against E, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q01484
- Every structure of UniProt Q8VIE5
- Elsewhere: RCSB PDB 6M3Q · PDBe 6M3Q · UniProt Q01484 · UniProt Q8VIE5
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