MolNFT v1 · #156264 · protein

Crystal structure of mimivirus ung Y322F in complex with ugi

6LYE · Probable uracil-DNA glycosylase: “Crystal structure of mimivirus ung Y322F in complex with ugi”. X-ray diffraction, 2 pockets (best druggability 0.55). MolNFT v1 #156264 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6LYE
Type: protein
Length: 353 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Probable uracil-DNA glycosylase; Uracil-DNA glycosylase inhibitor
EC: 3.2.2.-
UniProt: Q5UPT2, P14739
Pockets: 2 · best druggability 0.55

Structure

x-ray diffraction · 2 distinct chains · 32% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Probable uracil-DNA glycosylase (EC 3.2.2.-)	protein	271	35% helix, 12% strand	Q5UPT2
I	Uracil-DNA glycosylase inhibitor	protein	82	21% helix, 39% strand	P14739

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	197	0.55	0.79	39	empty
2	95	0.36	0.75	20	empty

Interfaces

1 interface between chains.

A–I · 1058 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

6LYE · Crystal Structure of mimivirus UNG Y322F in complex with UGI · the same entry in another collection · chain I against I, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5UPT2
Every structure of UniProt P14739
Elsewhere: RCSB PDB 6LYE · PDBe 6LYE · UniProt Q5UPT2 · UniProt P14739

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