MolNFT v1 · #156252 · protein
IRAK4 in complex with inhibitor
6LXY: “IRAK4 in complex with inhibitor”. X-ray diffraction, 2 ligands (EXF, SO4). MolNFT v1 #156252 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6LXY
- Type
- protein
- Length
- 1,172 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q9NWZ3
- Ligands
- EXF, SO4
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 294 | — | Q9NWZ3 |
| B | — | protein | 297 | — | Q9NWZ3 |
| D | — | protein | 293 | — | Q9NWZ3 |
| E | — | protein | 288 | — | Q9NWZ3 |
Ligands and binding sites
- EXF · N-[(2R)-2-fluoranyl-3-methyl-3-oxidanyl-butyl]-6-[(6-fluoranylpyrazolo[1,5-a]pyrimidin-5-yl)amino]-4-(propan-2-ylamino)pyridine-3-carboxamide · ligand · 4 copies · chains A, B, D, E
- SO4 · Sulfate ion · ion · 3 copies · chains A, B, D, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6LXY · IRAK4 in complex with inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NWZ3
- Elsewhere: RCSB PDB 6LXY · PDBe 6LXY · UniProt Q9NWZ3
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