MolNFT v1 · #156135 · protein
Trans-acting mutant Y290A of the central aaa+ domain of the flagellar regulatory protein flrc
6LUF · Flagellar regulatory protein C: “Trans-acting mutant Y290A of the central aaa+ domain of the flagellar regulatory protein flrc”. X-ray diffraction, 1 ligand (ADP), 20 pockets (best druggability 0.78). MolNFT v1 #156135 on GenesisL1…
- PDB
- 6LUF
- Type
- protein
- Length
- 1,725 residues
- Chains
- 7
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Flagellar regulatory protein C
- UniProt
- A0A0H3AHP1
- Ligands
- ADP
- Pockets
- 20 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, F | Flagellar regulatory protein C | protein | 247 | 42% helix, 14% strand | A0A0H3AHP1 |
| C, D, E, G | Flagellar regulatory protein C | protein | 246 | 42% helix, 15% strand | A0A0H3AHP1 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · 7 copies · chains A, B, C, D, E, F, G
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1043 | 0.78 | 0.80 | 98 | ADP |
| 2 | 984 | 0.78 | 0.80 | 97 | ADP |
| 3 | 1146 | 0.78 | 0.80 | 99 | ADP |
| 4 | 1063 | 0.78 | 0.80 | 103 | ADP |
| 5 | 1030 | 0.77 | 0.79 | 95 | ADP |
Interfaces
7 interfaces between chains.
- B–C · 887 Ų buried · 12 hydrogen bonds · protein-protein
- A–G · 871 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 868 Ų buried · 15 hydrogen bonds · protein-protein
- C–D · 865 Ų buried · 13 hydrogen bonds · protein-protein
- F–G · 864 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 6LUF · Trans-acting mutant Y290A of the central AAA+ domain of the flagellar regulatory protein… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0H3AHP1
- Elsewhere: RCSB PDB 6LUF · PDBe 6LUF · UniProt A0A0H3AHP1
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