MolNFT v1 · #156076 · protein
Structure of the E202Y mutant of the cl-/H+ antiporter clc-EC1 from E.COLI: a re-refined model of the 4FTP model
6LSC · H(+)/CL(-) exchange transporter clca: “Structure of the E202Y mutant of the cl-/H+ antiporter clc-EC1 from E.COLI: a re-refined model of the 4FTP…”. X-ray diffraction, 1 ligand (CL), 3 pockets (best druggability 0.69). MolNFT v1…
- PDB
- 6LSC
- Type
- protein
- Length
- 423 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- H(+)/CL(-) exchange transporter clca
- UniProt
- P37019
- Ligands
- CL
- Pockets
- 3 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 75% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | H(+)/CL(-) exchange transporter clca | protein | 423 | 75% helix, 1% strand | P37019 |
Ligands and binding sites
- CL · Chloride ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 337 | 0.69 | 0.83 | 32 | empty |
| 2 | 322 | 0.60 | 0.78 | 41 | empty |
| 3 | 100 | 0.38 | 0.75 | 16 | empty |
Compared structures
- 6LSC · Structure of the E202Y mutant of the Cl-/H+ antiporter CLC-ec1 from E.coli: a re-refined… · the same entry in another collection · chain A against A, TM-score 1.00
- P37019 · AlphaFold monomer V2.0 prediction for H(+)/CL(-) exchange transporter clca (P37019) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37019
- Elsewhere: RCSB PDB 6LSC · PDBe 6LSC · UniProt P37019
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