MolNFT v1 · #155982 · protein

Crystal structure of rat MUNC18-1 with K332E/K333E mutation

6LPC · Syntaxin-binding protein 1: “Crystal structure of rat MUNC18-1 with K332E/K333E mutation”. X-ray diffraction, 19 pockets (best druggability 0.77). MolNFT v1 #155982 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6LPC
Type: protein
Length: 1,000 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Syntaxin-binding protein 1
UniProt: P61765
Pockets: 19 · best druggability 0.77

Structure

x-ray diffraction · 2 distinct chains · 47% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Syntaxin-binding protein 1	protein	533	46% helix, 13% strand	P61765
B	Syntaxin-binding protein 1	protein	467	48% helix, 12% strand	P61765

Pockets

19 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	129	0.77	0.95	23	empty
2	674	0.73	0.79	83	empty
3	113	0.72	0.93	23	empty
4	423	0.71	0.81	64	empty
5	299	0.67	0.82	49	empty

Interfaces

1 interface between chains.

A–B · 1397 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

6LPC · Crystal Structure of rat Munc18-1 with K332E/K333E mutation · the same entry in another collection · chain A against A, TM-score 1.00
P61765 · AlphaFold monomer V2.0 prediction for syntaxin-binding protein 1 (P61765) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P61765
Elsewhere: RCSB PDB 6LPC · PDBe 6LPC · UniProt P61765

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