MolNFT v1 · #155956 · protein
Structure of CLHM1 from caenorhabditis elegans
6LOM · Calcium homeostasis modulator protein: “Structure of CLHM1 from caenorhabditis elegans”. Electron microscopy, 20 pockets (best druggability 0.85). MolNFT v1 #155956 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6LOM
- Type
- protein
- Length
- 5,900 residues
- Chains
- 20
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calcium homeostasis modulator protein
- UniProt
- Q18593
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 1 distinct chain · 66% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T | Calcium homeostasis modulator protein | protein | 295 | 66% helix, 0% strand | Q18593 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1114 | 0.85 | 0.86 | 151 | empty |
| 2 | 1016 | 0.85 | 0.86 | 139 | empty |
| 3 | 1009 | 0.85 | 0.86 | 145 | empty |
| 4 | 1102 | 0.85 | 0.85 | 140 | empty |
| 5 | 797 | 0.83 | 0.86 | 111 | empty |
Interfaces
60 interfaces between chains.
- I–J · 2738 Ų buried · 9 hydrogen bonds · protein-protein
- D–E · 2736 Ų buried · 9 hydrogen bonds · protein-protein
- R–S · 2736 Ų buried · 9 hydrogen bonds · protein-protein
- N–O · 2735 Ų buried · 9 hydrogen bonds · protein-protein
- M–N · 2731 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 80 disulfide (disulfide).
Compared structures
- 6LOM · Structure of CLHM1 from Caenorhabditis Elegans · the same entry in another collection · chain K against K, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q18593
- Elsewhere: RCSB PDB 6LOM · PDBe 6LOM · UniProt Q18593
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