MolNFT v1 · #155953 · protein
Crystal structure of enterococcus faecalis undecaprenyl pyrophosphate SYNTHASE(EFAUPPS)
6LOI · Isoprenyl transferase: “Crystal structure of enterococcus faecalis undecaprenyl pyrophosphate SYNTHASE(EFAUPPS)”. X-ray diffraction, 12 pockets (best druggability 0.78). MolNFT v1 #155953 on GenesisL1: 3D structure, binding sites…
- PDB
- 6LOI
- Type
- protein
- Length
- 1,341 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isoprenyl transferase
- EC
- 2.5.1.-
- UniProt
- A0A246M745
- Pockets
- 12 · best druggability 0.78
Structure
x-ray diffraction · 5 distinct chains · 47% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Isoprenyl transferase (EC 2.5.1.-) | protein | 217 | 46% helix, 15% strand | A0A246M745 |
| B, F | Isoprenyl transferase (EC 2.5.1.-) | protein | 222 | 46% helix, 14% strand | A0A246M745 |
| C | Isoprenyl transferase (EC 2.5.1.-) | protein | 235 | 46% helix, 13% strand | A0A246M745 |
| D | Isoprenyl transferase (EC 2.5.1.-) | protein | 223 | 52% helix, 13% strand | A0A246M745 |
| E | Isoprenyl transferase (EC 2.5.1.-) | protein | 222 | 46% helix, 14% strand | A0A246M745 |
Pockets
12 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 449 | 0.78 | 0.86 | 51 | empty |
| 2 | 222 | 0.69 | 0.85 | 25 | empty |
| 3 | 216 | 0.64 | 0.83 | 23 | empty |
| 4 | 196 | 0.63 | 0.83 | 26 | empty |
| 5 | 143 | 0.60 | 0.84 | 25 | empty |
Interfaces
10 interfaces between chains.
- B–C · 1674 Ų buried · 21 hydrogen bonds · protein-protein
- E–F · 1668 Ų buried · 19 hydrogen bonds · protein-protein
- A–C · 504 Ų buried · 12 hydrogen bonds · protein-protein
- A–D · 429 Ų buried · 5 hydrogen bonds · protein-protein
- B–D · 350 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 6LOI · Crystal structure of Enterococcus faecalis Undecaprenyl pyrophosphate synthase(EfaUPPS) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A246M745
- Elsewhere: RCSB PDB 6LOI · PDBe 6LOI · UniProt A0A246M745
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