MolNFT v1 · #155923 · protein + DNA + RNA
Cryoem structure of cascade-tniq-dsdna complex
6LNB · CRISPR-associated protein CAS7: “Cryoem structure of cascade-tniq-dsdna complex”. Electron microscopy, 20 pockets (best druggability 0.90). MolNFT v1 #155923 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6LNB
- Type
- protein + DNA + RNA
- Length
- 3,525 residues
- Chains
- 13
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CRISPR-associated protein CAS7; CRISPR-associated protein CAS8; CRISPR-associated protein…
- Pockets
- 20 · best druggability 0.90
Structure
electron microscopy · 13 distinct chains · 23% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| G | CRISPR-associated protein CAS7 | protein | 342 | 22% helix, 21% strand | — |
| F | CRISPR-associated protein CAS7 | protein | 336 | 22% helix, 21% strand | — |
| E | CRISPR-associated protein CAS7 | protein | 335 | 24% helix, 24% strand | — |
| D | CRISPR-associated protein CAS7 | protein | 336 | 23% helix, 23% strand | — |
| C | CRISPR-associated protein CAS7 | protein | 333 | 22% helix, 23% strand | — |
| B | CRISPR-associated protein CAS7 | protein | 301 | 22% helix, 23% strand | — |
| H | CRISPR-associated protein CAS8 | protein | 510 | 15% helix, 18% strand | — |
| A | CRISPR-associated protein CAS6 | protein | 197 | 16% helix, 11% strand | — |
| J | Transposition protein tniq | protein | 359 | 26% helix, 3% strand | — |
| M | CRISPR RNA (60-mer) | rna | 60 | — | — |
| N | Target DNA strand (51-mer) | dna | 33 | — | — |
| O | Non-target DNA strand (51-mer) | dna | 7 | — | — |
| I | Transposition protein tniq | protein | 376 | 34% helix, 8% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1031 | 0.90 | 0.92 | 130 | empty |
| 2 | 1083 | 0.84 | 0.85 | 92 | empty |
| 3 | 997 | 0.83 | 0.84 | 112 | empty |
| 4 | 1158 | 0.82 | 0.83 | 117 | empty |
| 5 | 1100 | 0.81 | 0.83 | 105 | empty |
Interfaces
36 interfaces between chains.
- G–F · 2169 Ų buried · 13 hydrogen bonds · protein-protein
- J–I · 2127 Ų buried · 28 hydrogen bonds · protein-protein
- F–E · 2121 Ų buried · 14 hydrogen bonds · protein-protein
- D–C · 2114 Ų buried · 23 hydrogen bonds · protein-protein
- E–D · 2027 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 6LNB · CryoEM structure of Cascade-TniQ-dsDNA complex · the same entry in another collection · chain G against G, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6LNB · PDBe 6LNB
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