MolNFT v1 · #155916 · protein
Estrogen-related receptor BETA(ERR2) in complex with PGC1A-2A
6LN4 · Steroid hormone receptor ERR2: “Estrogen-related receptor BETA(ERR2) in complex with PGC1A-2A”. X-ray diffraction, 2 pockets (best druggability 0.77). MolNFT v1 #155916 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6LN4
- Type
- protein
- Length
- 228 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Steroid hormone receptor ERR2; 10-mer from peroxisome proliferator-activated receptor…
- UniProt
- O95718, Q9UBK2
- Pockets
- 2 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 68% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Steroid hormone receptor ERR2 | protein | 218 | 68% helix, 2% strand | O95718 |
| B | 10-mer from peroxisome proliferator-activated receptor gamma coactivator 1-alpha | protein | 10 | 70% helix, 0% strand | Q9UBK2 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 91 | 0.77 | 0.97 | 26 | empty |
| 2 | 59 | 0.56 | 0.89 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 455 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 6LN4 · Estrogen-related receptor beta(ERR2) in complex with PGC1a-2a · the same entry in another collection · chain A against A, TM-score 1.00
- O95718 · AlphaFold monomer V2.0 prediction for steroid hormone receptor ERR2 (O95718) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q9UBK2 · AlphaFold monomer V2.0 prediction for peroxisome proliferator- activated receptor gamma… · a predicted model of the same protein · chain B against A, TM-score 0.73
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95718
- Every structure of UniProt Q9UBK2
- Elsewhere: RCSB PDB 6LN4 · PDBe 6LN4 · UniProt O95718 · UniProt Q9UBK2
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